Evaluation of alternative calculation methods for determining low-density lipoprotein cholesterol in hemodialysis patients

Objectives: To evaluate alternative equations for the estimation of low-density lipoprotein cholesterol (LDL-C) than the Friedewald equation in hemodialysis patients. Design and methods: The equations LDL-C = 0.41TC − 0.14TG + 0.66ApoB − 10.43 and LDL-C = 0.94TC − 0.94HDL-C − 0.19TG were evaluated in 86 patients and compared with the Friedewald equation and the ultracentrifugation procedure. Results: The alternative equations yield significantly lower bias than the Friedewald equation and are less affected by increased triglycerides (TG) levels. Conclusion: The alternative equations for LDL-C yield slightly better results than the Friedewald equation especially in hypertriglyceridemia.