Author/Authors :
Cristina B.O. Netto، نويسنده , , Luis V. Portela، نويسنده , , Cristina T. Ferreira، نويسنده , , Carlos Kieling، نويسنده , , Ursula Matte، نويسنده , , Têmis Felix، نويسنده , , Themis Reverbel da Silveira، نويسنده , , Diogo O. Souza، نويسنده , , Carlos Alberto Gonçalves، نويسنده , , Roberto Giugliani، نويسنده ,
Abstract :
Background:
It has been shown that Down syndrome (DS) patients have elevated S100B levels in brain tissue.
Design:
Measurements of S100B were performed in serum samples from 48 DS patients and 42 ostensibly healthy age-matched controls.
Results:
We observed higher levels of S100B in the DS group than in the control group. Moreover, serum S100B in DS patients was not age-dependent as it is in normal individuals.
Conclusion:
The higher levels of S100B in DS patients may reflect a general and persistent increase in the extracellular space and may be associated with neurodegenerative lesions observed in DS patients.
