Elevated TFPI levels in female hyperhomocysteinemic patients

Objectives: Hyperhomocysteinemia is a risk factor for cardiovascular diseases, while tissue factor pathway inhibitor (TFPI) regulates the extrinsic pathway of blood coagulation. We investigated the in vivo influence of elevated homocysteine concentrations on TFPI levels. Methods: Total TFPI levels of 82 hyperhomocysteinemic patients were determined. Results: The patientsʹ TFPI levels were significantly elevated compared to blood donors, with a more pronounced effect in females than in males. Conclusions: We have shown a gender-dependent TFPI elevation in hyperhomocysteinemic patients.