Cystatin C reference values and aging

Objectives: The aim of this study was to determine the reference values for serum cystatin C (CysC) with a particular focus on the effect of aging. Design and methods: The study was performed on a consecutive series of subjects (258 men and 396 women). Laboratory parameters and a detailed personal and family medical history were collected. Results: CysC showed a significant correlation with age in both sexes, which was confirmed with multivariate linear regression after adjustment for SCr (serum creatinine). Age-related reference intervals were established for cystatin C (< 45 years, < 0.95 mg/L and > 45 years, < 1.20 mg/L). Conclusions: The use of CysC reference values adjusted for age should be carefully taken into consideration.