Title of article :
Determination of glucuronidated 5-hydroxytryptophol (GTOL), a marker of recent alcohol intake, by ELISA technique
Author/Authors :
Jutta Dierkes، نويسنده , , Manfred Wolfersdorf، نويسنده , , Katrin Borucki، نويسنده , , Wolfgang Weinmann، نويسنده , , Gerhard Wiesbeck، نويسنده , , Olof Beck، نويسنده , , Stefan Borg، نويسنده , , Friedrich M. Wurst، نويسنده ,
Abstract :
Objectives:
To compare markers of alcohol consumption.
Design and methods:
Measurement of urinary ethyl glucuronide, 5-hydroxytryptophol, 5-hydroxytryptophol glucuronide, 5-hydroxyindole acetic acid in 10 patients during alcohol withdrawal.
Results:
5-Hydroxytryptophol glucuronide was measured by ELISA with good analytical precision, its diagnostic specificity and sensitivity was better than that of 5-hydroxytryptophol and its correlation was closer to ethyl glucuronide than to 5-hydroxytryptophol.
Conclusion:
Determination of 5-hydroxytryptophol glucuronide by ELISA offers promising results in detection of previous alcohol consumption.
