Levels of vascular cell adhesion molecule-1 and endothelin-1 in ischemic stroke: A longitudinal prospective study

Objectives To determine levels of vascular cellular adhesion molecule (VCAM)-1 and endothelin (ET)-1 in patients with stroke. Design and methods Thirty-four patients were prospectively studied. Plasma levels of VCAM-1 and ET-1 were measured by ELISA within 72 h of the event, at 7 and 90 days. Results Levels of VCAM-1 increased overtime, whereas ET-1 values were initially and persistently elevated. Conclusions Increased circulating levels of VCAM-1 and ET-1 are present during stroke.