Serum prolidase activity in patients with hypertension and its relation with left ventricular hypertrophy

Objectives: The purpose of this study was to determine serum prolidase activity in patients with hypertension and its relation with left ventricular hypertrophy. Design and methods: Serum prolidase activity was measured spectrophotometrically in hypertensive patients with (Group II, n = 30) and without left ventricular hypertrophy (Group III, n = 30) and in control group (Group I, n = 30). Results: Prolidase activity was significantly lower in Group I than in Groups II and III (44.64 ± 6.42 U/L vs. 54.14 ± 6.30 U/L and 54.25 ± 7.14 U/L, respectively; ANOVA, p < 0.001). We revealed significant correlation between prolidase activity and presence and duration of hypertension (both of p < 0.05) but not left ventricular mass index. Multivariate analysis shown that prolidase activity was significantly associated with age (β = 0.481, p < 0.001) and duration of hypertension (β = 0.396, p < 0.001). Conclusions: Our data show that serum prolidase activity is associated with the presence hypertension independent of left ventricular hypertrophy.