Association of endothelial protein C receptor haplotypes, factor V Leiden and recurrent first trimester pregnancy loss

Objectives We evaluated whether the endothelial protein C receptor (EPCR) haplotypes A1 and A3 exert effects on the development of recurrent pregnancy loss (RPL) in association with factor V Leiden. Design and methods We determined the EPCR haplotypes A1 and A3 and factor V Leiden in 49 women with a history of RPL and 48 parous controls. Results In carriers of factor V Leiden the A1 haplotype decreased the relative risk for RPL from 2.2 to 1.0. Conclusions The EPCR A1 haplotype tends to modulate the risk for RPL in carriers of factor V Leiden.