Head-to-head comparison of an automated immunometric and an automated HPLC method for the quantification of HbA1c

Objectives To compare a fully automated immunoassay and a fully automated HPLC method for the quantification of HbA1c. Design and methods For an inter-method comparison, 200 consecutive clinical samples were analyzed. Imprecision was studied with pooled whole blood. Results Very close agreement of results (identical mean result (6.0%); r = 0.99), and very similar reproducibility (total CV approximately 1%) were observed. Conclusions Both assays offer very similar analytical performance, although the analytical techniques used are completely different.