Title of article :
Volume-Referent Bone Turnover Estimated From the Interlabel Area Fraction After Sequential Labeling
Author/Authors :
T Frisch، نويسنده , , M.S S?rensen، نويسنده , , S Overgaard، نويسنده , , M Lind، نويسنده , , P Bretlau، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 1998
Pages :
6
From page :
677
To page :
682
Abstract :
In the compact bony otic capsule remodeling is low, and bone remodeling units are distributed centrifugally in relation to inner ear tissues and spaces. Fluorochrome-labeled bone remodeling units are scarce, abortive, and tortuous with no uniform direction of movement. This study presents a method for the estimation of volume-referent bone turnover based on measurements of the fractional area between labels after sequential labeling with osteofluorochromes. The applicability of this method is tested against a classical quantification method in undecalcified cortical specimens from the canine humerus, where both methods can be used. The estimate of bone turnover derived from the new sequential labeling in eight dogs is 7.4% (SEM 2.1%) per year and the classic estimate derived from calculations of the formative osteonal area and the formative period yields 6.9% (SEM 2.1%) per year. Agreement is sufficient to justify future measurements of absolute bone turnover in sequentially labeled perilabyrinthine bone.
Keywords :
Histomorphometry: Bone turnover: Bone rem.ldeling:Cortical bone: Tetracycline , Ca1cein.
Journal title :
Bone
Serial Year :
1998
Journal title :
Bone
Record number :
490641
Link To Document :
بازگشت