Bone mineral and soft tissue measurements by dual-energy x-ray absorptiometry during growth

There have been several previous compilations of reference ranges of total body bone mineral measured by dual-energy X-ray absorptiometry (DXA) in children and young adults during growth, but little attempt to compare the results or to consider differences arising from the use of instruments from different manufacturers. We measured bone mineral and soft tissue in 216 girls, aged 11–17 years, using a Hologic scanner. Our results were compared with those from four other studies, all performed on white subjects, but in different countries, and including measurements performed with Hologic, Lunar, and Norland scanners. The general pattern of bone growth with age was very similar in all the studies. Quantitative differences could largely be accounted for by known differences of calibration of DXA scanners from the different manufacturers. When bone mass was plotted against lean or total mass instead of age there were also close similarities. An apparent difference between boys and girls in one study was shown to be due to differences in soft tissue composition, rather than different patterns of bone growth. Conclusions from this apparent difference concerning the effect of estrogen at puberty were shown to be unwarranted.