Separation of beta-adrenolytics derived from 4hydroxyacetophenone by capillary electrophoresis in the presence of cyclodextrins

beta-Adrenolytics, derivatives of 4-(3-isobutylamino-2-hydroxypropoxy)-3-alkoxymethyl) acetophenone, synthesized from 4-hydroxyacetophenone and their enantiomers were separated by CE in presence of cyclodextrins or maltodextrin. Addition of maltodextrin into background electrolyte enhanced the efficiency of separation without chiral discrimination. The best separation of enantiomers of studied compounds was observed in presence of carboxymethylated beta-cyclodextrin. Migration time of studied compounds was correlated with a set of parameters (logP, dipole moment, molecular volume) calculated by methods of molecular modeling.