High-dose vitamin B6 treatment in West syndrome

Approximately 10–30% of patients with West syndrome respond to high-dose vitamin B6 treatment. The response to vitamin B6 is rapid; seizures disappear within the first 2 weeks of treatment. Mild side effects, such as gastrointestinal symptoms and liver dysfunction, are observed in 40–70%, but these resolve after discontinuation or a reduction of the dosage of vitamin B6. High-dose vitamin B6 treatment is useful as a first line agent in treating West syndrome.