Author/Authors :
Shinko Koishi، نويسنده , , Kenji Yamamoto، نويسنده , , Hideo Matsumoto، نويسنده , , Seiji Koishi، نويسنده , , Youichi Enseki، نويسنده , , Akitoshi Oya، نويسنده , , Arata Asakura، نويسنده , , Yutaka Aoki، نويسنده , , Mariko Atsumi، نويسنده , , Tomiei Iga، نويسنده , , Jyoji Inomata، نويسنده , , Hidetoshi Inoko، نويسنده , , Tsukasa Sasaki، نويسنده , , Eiji Nanba، نويسنده , , Nobumasa Kato، نويسنده , , Tetsuo Ishii، نويسنده , , Kosuke Yamazaki، نويسنده ,
Abstract :
Autism is now widely accepted as a biological disorder which, by and large, starts before birth. It has been shown that serotonin (5-HT) is associated with several psychological processes and hyperserotoninemia is observed in some autistic patients. The results of previous reports about family-based association studies between the serotonin transporter (5-HTT) gene promoter polymorphism and autism are controversial. In this study, an analysis using the transmission/disequilibrium test (TDT) between the 5-HTT gene promoter polymorphism and autism in 104 trios, all ethnically Japanese, showed no significant linkage disequilibrium (P=0.17). Recently, it has been reported that some haplotypes at the serotonin transporter locus may be associated with the pathogenesis of autism. Therefore, further investigations by haplotype analyses are necessary to confirm the implications of genetic variants of the serotonin transporter in the etiology of autism
Keywords :
AUTISM , Serotonin transporter (5-HTT) , Serotonin transporter gene promoter polymorphism , Transmission/disequilibrium test , Ethnic differences
