Title of article
Quantitative trait loci modulate vertebral morphology and mechanical properties in a population of 18-month-old genetically heterogeneous mice
Author/Authors
Grant M. Reeves، نويسنده , , Barbara R. Mccreadie، نويسنده , , Shu Chen، نويسنده , , Andrzej T. Galecki، نويسنده , , David T. Burke، نويسنده , , Richard A. Miller، نويسنده , , Steven A. Goldstein، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2007
Pages
11
From page
433
To page
443
Abstract
The aim of this study was to examine effects of polymorphic genes on vertebral bone morphology and mechanical properties. Genotypes from 525 18-month-old female mice were compared to geometric traits obtained from micro-computed tomography and mechanical properties from compression testing. Genetic markers were associated with traits on at least 13 different chromosomes, demonstrating the complexity of genetic control over vertebral form, function and aging.
Keywords
Genetic , Mice , Mechanical property , Geometry , quantitative trait loci
Journal title
Bone
Serial Year
2007
Journal title
Bone
Record number
496145
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