Issue Information
روزنامه با شماره پیاپی سال 2001
Pages
-194
From page
195
To page
0
Abstract
Ciprofloxacin is a broad spectrum fluoroquinolone antibacterial agent. In order to investigate the effect of cyclosporin A on the pharmacokinetics of ciprofloxacin in rats, a technique using blood microdialysis coupled to liquid chromatography was employed in this study. Microdialysis probe was inserted into the jugular vein/right atrium of male Sprague-Dawley rat for sampling of a protein unbound drug. The pharmacokinetics between i.v. doses of 20 or 50mg/kg ciprofloxacin were compared with those treated with a single i.v. dose of 20mg/kg cyclosporin A prior to the ciprofloxacin administrations. This study showed that a single dose treatment with cyclosporin A resulted in a significant increase in the pharmacokinetic parameters estimated for the higher dose of ciprofloxacin (50mg/kg) but no significant difference at the lower dose of ciprofloxacin (20mg/kg). The results suggest that cyclosporin A alters the pharmacokinetics of ciprofloxacin in rats. Possible mechanisms for this interaction include the blocking by cyclosporin A of the protein binding of ciprofloxacin with Pglycoprotein in rat blood.
Journal title
Analytica Chimica Acta
Serial Year
2001
Journal title
Analytica Chimica Acta
Record number
49652
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