K:Cl Cotransport Activity Is Inhibited by HCO−3 in Knockout Mouse Red Cells Expressing Human HbC,

K:Cl cotransport (KCl) was examined in transgenic mice expressing exclusively human hemoglobin C. In contrast to previous studies in early transgenic mice expressing human α and βS and residual mouse globins, we found significant volume and pH stimulation and sensitivity to . Exposure to physiological levels of also blocked a significant fraction of KCl cotransport.