Title of article :
Effects of tryptophan depletion on responses to yohimbine in healthy human subjects
Author/Authors :
Andrew W. Goddard، نويسنده , , Dennis S. Charney، نويسنده , , Mark Germine، نويسنده , , Scott W. Woods، نويسنده , , George R. Heninger، نويسنده , , John H. Krystal، نويسنده , , Wayne K. Goodman، نويسنده , , Lawrence H. Price، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 1995
Pages :
12
From page :
74
To page :
85
Abstract :
There is considerable evidence that both the norepinephrine (NE) and serotonin (5-HT) systems are involved in the regulation of human anxiety and fear responses. To assess the modulating effects of central 5-HT levels on NE function, 11 healthy human subjects were studied with placebo-controlled challenge tests involving tryptophan depletion followed by administration of the α-2-adrenergic antagonist yohimbine 0.4 mg/kg IV. Five of the 11 subjects reported a marked increase in feelings of nervousness ( 25 mm on a 100 mm analog scale) following the combination test, while 1/11 had this response to yohimbine alone. No subjects had an increase in nervousness during other control tests. The increase in nervousness after the tryptophan depletion—yohimbine test was statistically significant for the whole group, but there were no other unique changes in behavioral, physiologic or biochemical (MHPG, cortisol) variables with this test. These data are discussed in terms of possible functional interactions between the 5-HT and NE neurotransmitter systems.
Keywords :
Anxiety , serotonin. norepinephrine , tryptophan , MHPG. cortisol
Journal title :
Biological Psychiatry
Serial Year :
1995
Journal title :
Biological Psychiatry
Record number :
499552
Link To Document :
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