Title of article :
Electrocatalytic adsorptive voltammetry for fludarabine determination in urine
Author/Authors :
de-los-Santos-Alvarez، Noemi نويسنده , , Lobo-Castanon، M. Jesus نويسنده , , Miranda-Ordieres، Arturo J. نويسنده , , Tunon-Blanco، Paulino نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 2004
Pages :
-270
From page :
271
To page :
0
Abstract :
Fludarabine (F-Ara-A, 9-(beta)-D-arabinofuranosyl-2-fluoroadenine) is an arabinosyl nucleoside with potent cytotoxic activity against chronic lymphocytic leukemia. Herein, its electrochemical behavior is investigated on pyrolytic graphite electrodes (PGEs); and a novel catalytic adsorptive differential-pulse-voltammetric method for its determination is developed based on the strong electrocatalytic effect on nicotinamide adenine dinucleotide (NADH) oxidation exhibited by the oxidation products of F-Ara-A. This approach was applied to human urine samples, which required a previous solid-phase extraction. The F-Ara-A recovery was of 89.7%. The method proposed is fast, simple and permits detection of F-Ara-A concentrations up to 72 h after infusion.
Keywords :
Fludarabine , NADH , Catalytic adsorptive voltammetry
Journal title :
Analytica Chimica Acta
Serial Year :
2004
Journal title :
Analytica Chimica Acta
Record number :
49972
Link To Document :
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