Frontocortical activity in children with comorbidity of tic disorder and attention-deficit hyperactivity disorder

Comorbidity of tic disorder (TD) and attention-deficit hyperactivity disorder (ADHD) in children is common but not fully understood. Thus we investigated the effect of TD and ADHD on the amplitude of the postimperative negative variation (PINV) in children with combined tic + hyperactivity symptoms (TD + HA). PINV was chosen as an indicator of frontal lobe functioning that is closely related to self-regulation of behavior. PINVs of four groups of children (healthy controls, pure TD, pure ADHD, and combined TD + HA; total number 43) were elicited in an auditory warned reaction task in three conditions (control = CC, loss-of-control = LoCC, and lack-of-control = LaCC) at midfrontal (Fz) and midcentral (Cz) leads of the scalp. Effects of TD and ADHD were revealed only in the noncontrol conditions, being independent in the LaCC, but interactive in the LoCC. Thus, the additive model of psychopathological classification concerning the comorbidity of TD and ADHD was only partially supported by the observed pattern of psychophysiological results.