Author/Authors :
Alastair G. Cardno، نويسنده , , Timothy Bowen، نويسنده , , Carol A. Guy، نويسنده , , Lisa A. Jones، نويسنده , , Geraldine McCarthy، نويسنده , , Nigel M. Williams، نويسنده , , Kieran C. Murphy، نويسنده , , Gillian Spurlock، نويسنده , , Marion Gray، نويسنده , , Robert D. Sanders، نويسنده , , Nick Craddock، نويسنده , , Peter McGuffin، نويسنده , , Michael J. Owen، نويسنده , , Michael C. O’Donovan، نويسنده ,
Abstract :
Background: Long CAG repeats in the hKCa3 potassium channel gene have been associated with schizophrenia. We sought evidence for associations between this polymorphism and aspects of the schizophrenia phenotype.
Methods: Associations were investigated between CAG repeat length and gender, age of illness onset, and psychotic symptom dimensions in 203 unrelated individuals with DSM-IIIR schizophrenia.
Results: No association was found between CAG repeat length and gender or age of onset. Long CAG repeats were associated with higher negative symptom dimension scores.
Conclusions: This study provides preliminary evidence that genetic liability to negative symptoms in schizophrenia may be partly mediated through the hKCa3 gene.
Keywords :
Schizophrenia , Trinucleotide repeats , association , negative symptoms , Potassium channel
