Title of article :
Mapping brain size and cortical gray matter changes in elderly depression
Author/Authors :
Martina Ballmaier، نويسنده , , Elizabeth R. Sowell، نويسنده , , PAUL M. THOMPSON، نويسنده , , Anand Kumar، نويسنده , , Katherine L. Narr، نويسنده , , Helen Lavretsky، نويسنده , , Suzanne E. Welcome، نويسنده , , Heather DeLuca، نويسنده , , Arthur W. Toga، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 2004
Pages :
8
From page :
382
To page :
389
Abstract :
Background In elderly depression, volumetric brain imaging findings suggest abnormalities of the frontal lobe, particularly the orbitofrontal cortex, and the hippocampus. No studies to date have mapped cortical abnormalities over the entire brain surface in major depression. Here, we conducted detailed spatial analyses of brain size and gray matter within the cortical mantle in elderly patients with major depression. Methods High-resolution, three-dimensional, structural magnetic resonance imaging data and cortical pattern matching methods were used in 24 depressed elderly patients and 19 group-matched controls to measure local brain size and proportions of gray matter at thousands of homologous cortical surface locations. Results Prominent brain size reductions were observed in the depressed subjects in the orbitofrontal cortex bilaterally. Cortical gray matter measurements revealed significant gray matter increases in the orbitofrontal cortex, adjacent to focal trend level significant decreases of gray matter in the same region. Depressed patients also exhibited significant gray matter increases in parietal cortices, as well as the left temporal cortex. Conclusions Complex cortical changes may contribute to the brain size reduction of the orbitofrontal cortex and to the gray matter abnormalities detected in orbitofrontal cortex and temporoparietal cortices, thereby providing a potentially new window into the pathophysiology of elderly depression.
Keywords :
MRI , temporoparietal cortices , OFC , geriatric depressivedisorder , Morphometry , pathophysiology
Journal title :
Biological Psychiatry
Serial Year :
2004
Journal title :
Biological Psychiatry
Record number :
502253
Link To Document :
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