Title of article :
Association analysis of FEZ1 variants with schizophrenia in Japanese cohorts
Author/Authors :
Kazuo Yamada، نويسنده , , Kazuhiko Nakamura، نويسنده , , Yoshio Minabe، نويسنده , , Yoshimi Iwayama-Shigeno، نويسنده , , Hitomi Takao، نويسنده , , Tomoko Toyota، نويسنده , , Eiji Hattori، نويسنده , , Noriyoshi Takei، نويسنده , , Yoshimoto Sekine، نويسنده , , Katsuaki Suzuki، نويسنده , , Yasuhide Iwata، نويسنده , , Ko Miyoshi، نويسنده , , Akiko Honda، نويسنده , , Kousuke Baba، نويسنده , , Taiichi Katayama، نويسنده , , Masaya Tohyama، نويسنده , , Norio Mori، نويسنده , , Takeo Yoshikawa، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 2004
Pages :
8
From page :
683
To page :
690
Abstract :
Background
DISC1 has been suggested as a causative gene for psychoses in a large Scottish family. We recently identified FEZ1 as an interacting partner for DISC1. To investigate the role of FEZ1 in schizophrenia and bipolar disorder, case–control association analyses were conducted in Japanese cohorts.
Methods
We performed a mutation screen of the FEZ1 gene and detected 15 polymorphisms. Additional data on informative polymorphisms were obtained from public databases. Eight single nucleotide polymorphisms (SNPs) were analyzed in 119 bipolar disorder and 360 schizophrenic patients and age- and gender-matched control subjects. All genotypes were determined with the TaqMan assay, and selected samples were confirmed by sequencing.
Results
The two adjacent polymorphisms displayed a nominally significant association with schizophrenia (IVS2+1587G>A, p = .014; 396T
Keywords :
DISC1 , linkagedisequilibrium block , case– control study , Neurodevelopment , Chromosome 11q , protein kinase C
Journal title :
Biological Psychiatry
Serial Year :
2004
Journal title :
Biological Psychiatry
Record number :
502469
Link To Document :
