Author/Authors :
Joanna S. Fowler، نويسنده , , Nelly Alia-Klein، نويسنده , , Aarti Kriplani، نويسنده , , Jean Logan، نويسنده , , Benjamin Williams، نويسنده , , Wei Zhu، نويسنده , , Ian W. Craig، نويسنده , , Frank Telang، نويسنده , , Rita Goldstein، نويسنده , , Nora D. Volkow، نويسنده , , Paul Vaska، نويسنده , , Gene-Jack Wang، نويسنده ,
Abstract :
Background
A functional polymorphism in the promoter region of the monoamine oxidase A (MAO A) gene has two common alleles that are referred to as the high and low MAO A genotypes. We report the first in vivo human study to determine whether there is an association between MAO A genotype and brain MAO A activity in healthy male subjects.
Methods
Brain MAO A activity was measured with positron emission tomography and [11C]clorgyline in 38 healthy adult male nonsmokers genotyped for MAO A polymorphism.
Results
There was no significant difference in brain MAO A activity between the high (n = 26) and low (n = 12) MAO A genotypes.
Conclusions
The lack of an association between the high and low MAO A genotype and brain MAO A activity suggests that this polymorphism by itself does not contribute to differences in brain MAO A activity in healthy adult male subjects.
