Title of article :
Connectivity Between Posterior Parietal Cortex and Ipsilateral Motor Cortex Is Altered in Schizophrenia
Author/Authors :
Giacomo Koch، نويسنده , , Michele Ribolsi، نويسنده , , Francesco Mori، نويسنده , , Lucia Sacchetti، نويسنده , , Claudia Codecà، نويسنده , , Ivo Alex Rubino، نويسنده , , Alberto Siracusano، نويسنده , , Giorgio Bernardi، نويسنده , , Diego Centonze، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 2008
Abstract :
Background
Recent advances have highlighted the hypothesis of schizophrenia as a disorder causing defective connectivity among distinct cortical regions. Neurophysiological evidence supporting this hypothesis, however, is still lacking.
Methods
In the present study, we used a novel twin-coil transcranial magnetic stimulation (tcTMS) approach to investigate ipsilateral parieto-motor connectivity in 20 schizophrenic patients (14 medicated, 6 unmedicated) and in 15 healthy age-matched volunteers.
Results
In healthy subjects, a conditioning TMS pulse applied over the ipsilateral posterior parietal cortex (PPC) at 90% of resting motor threshold (RMT) intensity was able to increase the excitability of the hand area of the right primary motor cortex, with peaks at interstimulus intervals (ISIs) of 4 and 15 msec. This paradigm of stimulation failed to reveal any facilitatory parieto-motor interaction in medicated and unmedicated schizophrenic patients. The between-group difference in paired-pulse facilitation was not ISI-specific. In following analyses, we found that the effects across ISIs induced by PPC conditioning at 90% RMT correlated with the Global Assessment Functioning score and with the negative subscale of the Positive and Negative Syndrome Scale, showing that patients with a better global functioning and lower negative symptoms had less impaired connectivity. Moreover the same parameter correlated with illness duration.
Conclusions
Parieto-motor connectivity is impaired in schizophrenia. Cortico–cortical disconnection might be a core feature of schizophrenia.
Keywords :
Parietal cortex , Schizophrenia , connectivity , TMS , Transcranial magnetic stimulation
Journal title :
Biological Psychiatry
Journal title :
Biological Psychiatry