Effect of α-tocopherol pretreatment on high energy metabolites in rabbit skeletal muscle after ischemiareperfusion

9. Effect of α-tocopherol pretreatment on high energy metabolites in rabbit skeletal muscle after ischemiareperfusion Pages 85-87 A. Punz, J. Nanobashvili, A. Fuegl, I. Huk, E. Roth Preview Purchase PDF (324 K) | Related Articles Abstract | References Abstract The ability of skeletal muscle to recover high energy phosphate compounds in response to pretreatment with vitamin E was investigated in a rabbit hindlimb ischemia/reperfusion model (2.5 h/2 h). High energy metabolites were measured in the adductor magnus muscle of untreated animals and compared to the treatment group (all rac-α-tocopheryl acetate, 3 mg/kg body weight, supplemented i.v. before the onset of ischemia). Phosphocreatine (PCr) levels decreased after ischemia more than 65% in untreated and treatment groups, but tended to recover in treatment group after reperfusion. Adenosine triphosphate (ATP) values decreased by 50% of basal level after reperfusion in the untreated group, whereas α-tocopherol pretreatment prevented ATP depletion. Short Report