Title of article :
The effect of a combination of plant sterol-enriched foods in mildly hypercholesterolemic subjects
Author/Authors :
Martin B. Madsen، نويسنده , , Anne-Mette Jensen، نويسنده , , Erik B. Schmidt، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 2007
Abstract :
Background & aims
The purpose of this study was to evaluate the effect of low-fat products enriched with plant sterols in addition to a National Cholesterol Education Program step 1 diet on serum lipids and lipoproteins.
Methods
This study was a double-blind, randomised, placebo-controlled cross-over design with a run-in period and 2 intervention periods, each lasting 4 weeks. A total of 46 mildly hypercholesterolemic subjects (age 50.6±9.8) completed the trial. The study products consisted of 20 g low-fat margarine (35% fat) and 250 ml low-fat milk (0.7% fat), in total delivering 2.3 g plant sterols/d.
Results
Serum total and low-density lipoprotein cholesterol were significantly reduced by 5.5% (p<0.001, 95% CI: 2.5; 8.3) and 7.7% (p=0.001, 95% CI: 3.4; 11.9), respectively, by plant sterol-enriched products compared to placebo. Serum apolipoprotein B was significantly reduced by 4.6% (p<0.05, 95% CI: 1.7; 7.5), and apolipoprotein B/apolipoprotein A-I by 3.4% (p<0.05, 95% CI: 0.1; 6.6) after plant sterol intake compared to the placebo supplement.
Conclusions
A combination of low-fat margarine and milk enriched with plant sterols significantly reduced low-density lipoprotein cholesterol, apolipoprotein B and the ratio of apolipoprotein B to apolipoprotein A-I in mildly hypercholesterolemic subjects, but had no effect on C-reactive protein and lipoprotein (a) concentrations.
Sponsorship
Unilever Denmark A/S.
Keywords :
LDL cholesterol , Apolipoprotein B , apolipoprotein A-I , Phytosterols , Coronary Heart Disease
Journal title :
Clinical Nutrition
Journal title :
Clinical Nutrition