A delayed hypersensitivity reaction to dentine primer in the guinea-pig

Objective: This study was undertaken to examine the possibility of a delayed hypersensitivity reaction or contact dermatitis occurring in the guinea-pig in response to methacrylate derivatives used as experimental dentine primers. Method: The dentine primers 2-HEMA, GM, MA and MMA were tested in a guinea-pig maximization test. Results: All the dentine primers tested produced positive delayed hypersensitivity reactions in the guinea-pig. MMA produced the most severe reaction. Conclusion: It is concluded that in the clinical situation, clinicians and other members of the dental team should be aware of the need for careful handling of the dentine primers tested.