Clinico-pathological correlation of glucagon-positive pancreatic endocrine tumours: a presentation of five cases

The clinicopathologic correlation of five cases of glucagon-positive pancreatic tumours is reviewed. Two cases with the typical glucagonoma syndrome but with atypical manifestations in the central nervous system are presented. These neurological manifestations might constitute a new paraneoplastic syndrome. The last three cases illustrate how glucagon positivity can be present in pancreatic endocrine tumours other than in the classical glucagonoma.