Preoperative radiotherapy for soft tissue sarcoma: The Peter MacCallum Cancer Centre experience

Aim Radiotherapy has been shown to improve local control in combination with limb-sparing or conservative surgery in the management of localised soft tissue sarcoma. Our centreʹs treatment protocol is to offer preoperative external beam radiotherapy (50.4 Gy in 28 fractions) followed by surgery four to six weeks later. The aim of this study is to review the treatment outcome and toxicity of patients treated with this protocol. Methods Consecutive patients with localised extremity or truncal soft tissue sarcoma who presented between January 1996 and December 2000 and treated with preoperative radiotherapy followed by limb-sparing surgery were reviewed. Patients with recurrent disease or metastatic disease at diagnosis and patients below the age of 16 years were excluded. Local and distant recurrence, overall survival and treatment toxicity were analyzed. Results Sixty-seven cases were identified (41 males and 26 females). The median age was 52 years (range 17 to 82). The majority (79%) had tumours located in the lower limb. The most common histological diagnoses were malignant fibrous histiocytoma and liposarcoma. The median follow-up was 4.1 years (range 0.6 to 6.9). There were six local recurrences, two of which were successfully salvaged. Twenty patients developed distant metastases. The estimated 5-year actuarial local recurrence free, distant recurrence free and overall survival were 93%, 68% and 73% respectively. Acute radiotherapy toxicity and wound complications were acceptable and late toxicity was uncommon. Conclusion Preoperative radiotherapy followed by surgery provides effective local control in the management of soft tissue sarcoma.