Polymorphisms of short tandem repeat of genes and breast cancer susceptibility

Aim To explore the relationship of short tandem repeat polymorphisms and breast cancer susceptibility. Methods We searched the MEDLINE database (up to June 2006) with the keywords of tandem repeat sequences, gene polymorphisms, breast cancer, cancer susceptibility and microsatellite instability. We reviewed the literature on gene polymorphisms, especially the relationship of short tandem repeat and breast cancer risk. Results We focused on the candidate genes sex hormones, steroid hormone and receptors, carcinogen metabolism, cell proliferation regulation and other genes. Conclusions The functional effects of short tandem repeat polymorphisms on cancer susceptibility, especially on breast cancer risk, are identified. The importance of short tandem repeat polymorphisms on development and progression of breast cancer are discussed.