Early αβ T cell development in the thymus of normal and genetically altered mice

The vast majority of T lymphocytes, with the exception of gut-associated, intraepithelial lymphocytes, differentiate and mature inside the thymus. Early T cell development is characterized by expansion and differentiation of thymocytes which do not yet express mature TCRs on their cell surface. Important events in early thymocyte development are controlled by a pre-TCR complex consisting of a conventional TCRβ chain and a novel transmembrane protein temmed pre-TCRα (pTα chain) which are noncovalently associated with components of CD3. Recent studies of pre-TCR function have led to a better understanding of the molecular events in early thymocyte development.