Biochemical, cell biological and immunological issues surrounding the endoplasmic reticulum chaperone GRP94/gp96

The past year has born witness to compelling demonstrations of the utility of peptide complexes with glucose regulated protein 94 (GRP94, also known as gp96) in cancer immunotherapy. Insights into structural basis of peptide binding to GRP94 have been obtained and the role of the transporter for antigen presentation defining the GRP94-bound peptide composition has been determined