Title of article
Clinical applications of TNF-α in cancer
Author/Authors
Ferdy J Lejeune، نويسنده , , Curzio Rüegg، نويسنده , , Danielle Liénard، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 1998
Pages
8
From page
573
To page
580
Abstract
High-dose TNF-α plus chemotherapy, with or without IFN-γ, can be safely administered regionally through isolated limb perfusion. This procedure produced between 70% and 80% complete remission in cases of in transit melanoma metastases and between 25% and 36% complete remission in cases of inextirpable soft-tissue sarcomas. Dual targeting is involved; TNF-α and IFN-γ induce apoptosis of angiogenic endothelium, while melphalan induces apoptosis of tumour cells.
Journal title
Current Opinion in Immunology
Serial Year
1998
Journal title
Current Opinion in Immunology
Record number
511776
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