Author/Authors :
Harald von Boehmer، نويسنده , , Iannis Aifantis، نويسنده , , Jacqueline Feinberg، نويسنده , , Oskar Lechner، نويسنده , , Claude Saint-Ruf، نويسنده , , Ulrich Walter، نويسنده , , Jan Buer، نويسنده , , Orly Azogui، نويسنده ,
Abstract :
The construction of various gene-deficient mice has facilitated the understanding of the role of various receptors and signaling pathways that control the generation of αβ lineage cells. A predominant role is occupied by the pre-TCR, which not only generates large numbers of a lineage cells but also controls TCRβ allelic exclusion as well as commitment to the γδ lineage versus the a lineage.
