Title of article :
Immune responses to adenoviruses: viral evasion mechanisms and their implications for the clinic
Author/Authors :
William SM Wold، نويسنده , , Konstantin Doronin، نويسنده , , Karoly Toth، نويسنده , , Mohan Kuppuswamy، نويسنده , , Drew L Lichtenstein، نويسنده , , Ann E Tollefson، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 1999
Pages :
7
From page :
380
To page :
386
Abstract :
Adenoviruses encode proteins that block responses to interferons, intrinsic cellular apoptosis, killing by CD8+ cytotoxic T lymphocytes and killing by the death ligands TNF, Fas ligand and TRAIL. The viral proteins are believed to prolong acute and persistent adenovirus infections. The proteins may prove useful in protecting adenovirus gene therapy vectors and transplanted cells from the immune system.
Journal title :
Current Opinion in Immunology
Serial Year :
1999
Journal title :
Current Opinion in Immunology
Record number :
511854
Link To Document :
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