Transcriptional control of T cell development

Transcriptional control of T cell development is a complex and rapidly moving area of investigation. Recent advances reveal critical roles for several transcription factors in T cell commitment, differentiation and selection. In particular, new roles for E proteins as well as members of the Notch signaling pathway have been described. Additionally a unique function of Ikaros in chromatin remodeling reveals a novel mechanism by which transcriptional control may be exerted.