CD1-restricted antigen presentation: an oily matter

CD1 molecules control diverse immune functions by presenting self and non-self lipid antigens to T lymphocytes. The recent solution of the human CD1b structure has revealed the first principles for the structural basis of the presentation of unique and overlapping sets of lipids. Additionally, new studies have shed light on the unique aspects of intracellular CD1 traffic, lipid antigen processing and T cell recognition of non-peptidic ligands.