Cellular orchestration of T cell priming in lymph nodes

Progress made in visualizing T cell responses in vivo and at the single cell level has revealed an unexpected level of complexity in the orchestration of T cell activation in lymph nodes. The choreography that leads to the initiation of a T cell response involves multiple cellular actors, and is intrinsically influenced by their motility and their mode of cell–cell interactions. Recent studies have begun to depict the cellular orchestration of T cell priming and to analyze the way it could influence the outcome of T cell responses.