Title of article :
Molecular machinations of the MHC-I peptide loading complex
Author/Authors :
Anthony W. Purcell، نويسنده , , Tim Elliott، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 2008
Abstract :
The acquisition of an optimal peptide ligand by MHC class I molecules is crucial for the generation of immunity to viruses and tumors. This process is orchestrated by a molecular machine known as the peptide loading complex (PLC) that consists of specialized and general ER-resident molecules. These proteins collaborate to ensure the loading of an optimal peptide ligand into the antigen binding cleft of class I molecules. The surprising diversity of peptides bound to MHC class I molecules and recapitulation of class I assembly in vitro have provided new insights into the molecular machinations of peptide loading. Coupled with the extraordinary polymorphism of class I molecules and their differential dependence on various components of the PLC for cell surface expression, a picture of peptide loading at the molecular level has recently emerged and will be discussed herein.
Journal title :
Current Opinion in Immunology
Journal title :
Current Opinion in Immunology