Title of article
4-Hydroxynonenal-Induced Relaxation of Human Mesenteric Arteries
Author/Authors
Francisco J. Romero، نويسنده , , Mar?a Jes?s Romero، نويسنده , , Francisco Bosch-Morell، نويسنده , , M. Carmen Mart?nez، نويسنده , , Pascual Medina، نويسنده , , Salvador Lluch، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 1997
Pages
3
From page
521
To page
523
Abstract
The effect of 4-hydroxynonenal (4-HNE), a circulating lipid peroxidation product, on the vascular tone of human mesenteric arteries is studied. 4-HNE promotes relaxation of human mesenteric arterial rings in a concentration-dependent manner. Removal of the endothelium or treatment with NG-nitro-image-arginine methyl ester hydrochloride (L-NAME; 10−4 M) partially prevented 4-HNE-induced relaxation, thus suggesting the intervention of nitric oxide from endothelial origin in the vascular effects of 4-HNE.
Keywords
nitric oxide , oxidative stress , Hepatic damage , Lipid peroxidation , Microcirculatory regulation
Journal title
Free Radical Biology and Medicine
Serial Year
1997
Journal title
Free Radical Biology and Medicine
Record number
517661
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