Title of article
Comparison of Oxidative Base Damage in Mitochondrial and Nuclear DNA
Author/Authors
Tomasz H. Zastawny، نويسنده , , Magdalena Dabrowska، نويسنده , , Tomasz Jaskolski، نويسنده , , Maciej Klimarczyk، نويسنده , , Lubomir Kulinski، نويسنده , , Agnieszka Koszela، نويسنده , , Maciej Szczesniewicz، نويسنده , , Magdalena Sliwinska، نويسنده , , Piotr Witkowski، نويسنده , , Ryszard Olinski، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 1998
Pages
4
From page
722
To page
725
Abstract
The levels of endogenous pig liver cells mitochondrial DNA oxidative base damage have been investigated using isotope dilution gas chromatography mass spectrometry (GC/MS). Higher levels of five measured bases were found in mtDNA in relation to nuclear DNA. We have also detected large differences in the modified base ratios of mitochondrial versus nuclear DNA. These ratios for the bases with promutagenic properties as 8OHGua and 5OHCyt are much lower then for other bases (5OHHyd, 5OHMeHyd, 5OHMeUra).
Keywords
DNA damage , mitochondrial DNA , free radicals , oxidative damage
Journal title
Free Radical Biology and Medicine
Serial Year
1998
Journal title
Free Radical Biology and Medicine
Record number
517811
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