Title of article :
Neurophysiological evaluation of vigilance in epileptic patients on monotherapy with lamotrigine
Author/Authors :
E. Bonanni، نويسنده , , R. Galli، نويسنده , , S. Gori، نويسنده , , L. Pasquali، نويسنده , , M. Maestri، نويسنده , , A. Iudice، نويسنده , , L. Murri، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 2001
Pages :
5
From page :
1018
To page :
1022
Abstract :
Objective: Limited research has focused to date on daytime sleepiness in epileptic patients treated with either conventional or newer antiepileptic drugs. We evaluated the level of vigilance in 15 consecutive, newly diagnosed and never medicated adult epileptic patients, receiving initial monotherapy with lamotrigine (LTG). Methods: Patients underwent the Multiple Sleep Latency Test (MSLT), visual reaction times (VRT) and Stanford Sleepiness Scale (SSS) on two separate occasions, i.e. before and 2 months after LTG treatment. A group of 15 age-matched healthy volunteers was taken as control. Results: At baseline, mean sleep latencies on the MSLT were comparable in epileptic patients and in controls. In patients, 2 months after monotherapy with LTG 200 mg/day, MSLT scores did not significantly change as compared with pre-treatment values. Accordingly, subjective evaluation of vigilance by the SSS and psychomotor performance by VRT were superimposable in controls and in untreated patients, and did not change in patients after LTG treatment. Conclusions: These results suggest that in adult, newly diagnosed epileptic patients initial monotherapy with LTG does not impair vigilance.
Keywords :
sleepiness , Multiple Sleep Latency Test , Epilepsy , lamotrigine
Journal title :
Clinical Neurophysiology
Serial Year :
2001
Journal title :
Clinical Neurophysiology
Record number :
522204
Link To Document :
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