Preconditioning stimuli and inadvertent preconditioning

Preconditioning Stimuli and Inadvertent Preconditioning. Journal of Molecular and Cellular Cardiology (1995) 27, 743–747. There are several factors besides brief episodes of total coronary occlusion which can provide sufficient stress to result in a preconditioning-like effect on the size of a myocardial infarction. Partial coronary artery stenosis, hypoxia, stretch, catecholamines, rapid pacing, and certain pharmacologic therapies may provide preconditioning stimuli. These same factors as well as mechanical complications in which a coronary artery is briefly occluded or stenosed prior to a subsequent coronary occulsion may lead to inadvertent preconditioning and confound the results of experimental cardiology studies.