Author/Authors :
A. J. Conrad Smith، نويسنده , , Robert E. Holt، نويسنده , , Kelly Fitzpatrick، نويسنده , , Igor F. Palacios، نويسنده , , Herman K. Gold، نويسنده , , Wendy Werner، نويسنده , , Edwin G. Bovill MD for the GUSTO-I Hemostasis Substudy Group، نويسنده , , Valentin Fuster، نويسنده , , Ik-kyung Jang، نويسنده ,
Abstract :
Clinical and biochemical evidence of a rebound phenomenon after discontinuing thrombin inhibitors has been reported in patients with unstable angina. To investigate if a similar phenomenon occurs in patients undergoing coronary angioplasty, 14 patients were prospectively studied during and after discontinuation of heparin infusion. A transient thrombotic state identified by a significant increase in a polypeptide fragment and fibrinopeptide A was observed 3 hours after abruptly discontinuing heparin infusion. This observation may be clinically important in managing patients after coronary angioplasty.
