Local Cardiac Renin–Angiotensin System: Hypertension and Cardiac Failure

J. Varagic and E. D. Frohlich. Local Cardiac Renin–Angiotensin System: Hypertension and Cardiac Failure. Journal of Molecular and Cellular Cardiology (2002) 34, 1435–1442. In addition to the effect on arterial pressure, angiotensin II, the effector peptide of the renin–angiotensin system (RAS), exerts mitogenic and growth promoting effects on cardiac myocytes and non-myocytic elements; and both of these effects significantly contribute to the development and progression of hypertensive heart disease (HHD). The traditional concept of the RAS as a systemic, endocrine system has been expanded and the identification of its components in many organs and tissue has been amassed. This paper reviews evidence that supports the concept that the cardiac RAS participate importantly in the development and risk of HHD.