Author/Authors :
Kavita K. Katti، نويسنده , , Prahlad R. Singh، نويسنده , , Wynn A. Volkert، نويسنده , , Carolyn J. Anderson، نويسنده , , M. J. Welch، نويسنده , , Timothy Hoffman، نويسنده , , Kattesh V. Katti، نويسنده , , Alan R. Ketring، نويسنده , , Meifang Wang، نويسنده ,
Abstract :
Ph3PNSiMe3 reacts with 99mTcO4− to form an ion pair that in soluble in organic solvents. Heating of the ion pair produces a new 99mTc species that is neutral and lipophilic and stable in dry toluene for greater-or-equal, slanted 2 h. Dissolving this new complex in 1:1, EtOH:H2O results in conversion of the product back to the ion pair which will limit its in vitro and in vivo stability. The chromatographic properties of the ion pair and the 99mTc species produced when heated in toluene are similar to the analogous Re complexes with Ph3PNSiMe3 which should have the following respective structures: [Ph3PNH2+][99mTcO4−] and Ph3PN99mTcO3. These results indicate the potential of phosphinimine ligands in formulation of new 99mTc radiopharmaceuticals, particularl if phosphinimine ligand derivatives are developed that provide substantially improved stability of the respective complexes in aqueous solutions.
