Synthesis of [11C]methyl magnesium iodide and its application to the introduction of [11C]-N-tert-butyl groups and [11C]-sec-alcohols

The 11C labelled Grignard reagent methyl magnesium iodide was synthesized carrier and non-carrier added from [11C]methyl iodide and magnesium. This new 11C-synthon was applied in the synthesis of a [11C]-N-tert-butyl group by reaction with 2,2,3,4-tetramethyl-5-oxazolidine and in the synthesis of 11C-sec-alcohols by reaction with benzaldehyde and 3-phenylpropionaldehyde. The radiochemical yield was 18–29% (not corrected for decay) with a synthesis time of 18 min (from [11C]CH3I). In the case of 2,2,3,4-tetramethyl-5-phenyl-oxazolidine an one-pot synthesis was developed according to the Barbier method.