Studies on the synthesis of 16α-[18F]fluoroestradiol

For preparing 16α-[18F]fluoroestradiol, a new one-pot procedure reported in the literature was elaborated in detail. The experimental conditions for synthesizing the required precursor and for converting it into 16α-fluoroestradiol or 16α-[18F]fluoroestradiol are given. The synthesis consists of the fluoridation reaction and hydrolysis reactions. For rapid hydrolysis of the fluorosteroid formed in the fluoridation reaction two methods are presented. The synthesis time does not exceed 1 h. Pure 16α-[18F]fluoroestradiol can be obtained in a 70% overall radiochemical yield.