Cytogenetic investigation of occupationally irradiated persons a long time after exposure

Chromosomal analyses were performed in blood lymphocytes of 33 persons previously occupationally exposed to ionizing radiation. An increased frequency of chromosome aberrations, mainly dicentrics, a long time, up to 47 years after exposure, suggests that it is possible to use the method of unstable aberration analysis for assessment of previous radiation exposure. The enhanced yield of dicentrics was observed in persons who may have received irradiations above permitted limits. The aberrations represent a residue from a higher initially induced incidence. They can not be used reliably for retrospective dosimetry but do provide a marker for old exposure.